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AMPHOTERICIN B LIPOSOMAL

  • API - Amphotericin B Liposomal
  • Packaging - Intravenous Powder for Injection
  • Strength - 50 mg

What is Amphotericin B Liposomal, and what it is used for?

Amphotericin B Liposomal Injection is an antifungal and an antiprotozoal medicine used for:

  • Treatment of Cryptococcal Meningitis in HIV infected patients.
  • Empirical therapy for presumed fungal infection in febrile, neutropenic patients.
  • Treatment of visceral leishmaniasis
  • Treatment of patients with Aspergillus species, Candida species and/or Cryptococcus species infections refractory to amphotericin B deoxycholate, or in patients where renal impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate.
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Dosage

Dosage of Liposomal Amphotericin B should be administered by intravenous infusion, using a controlled infusion device, over a time period of approximately 120 minutes.

The recommended initial dose of liposomal amphotericin b 50 mg injection for each indication for adults and pediatric patients is as follows:

  • For Empirical therapy: Dose is 3 mg/kg/day.
  • For Systemic fungal infections (Aspergillus, Candida, Cryptococcus): Dose is 3-5 mg/kg/day.
  • Cryptococcal meningitis in HIV infected patients: Dose is 6 mg/kg/day.

Standard doses of injection of liposomal amphotericin b for visceral leishmaniasis are as follows:

  • For Immunocompetent patients: Dose is 3 mg/kg/day (days 1-5) and 3 mg/kg/day on days 14, 21.
  • For Immunocompromised patients: Dose is 4 mg/kg/day (days 1-5) and 4 mg/kg/day on days 10, 17, 24, 31, 38.
Side effects

The most commonly reported side effects due to liposomal amphotericin b injection include: fever, chills, emesis, nephrotoxicity, hypokalemia, increased serum creatinine, and infusion related adverse events.

Warnings And Precautions
  • As with any amphotericin B-containing product the medicine should be given by a medically trained personnel. During the first dosing period, patients should be under precise clinical observation. This drug is significantly less toxic than amphotericin B deoxycholate; however, side effects may still occur.
  • Anaphylaxis may appear with amphotericin B deoxycholate and other existing amphotericin B-containing medicines, including liposomal amphotericin injection. In case a severe anaphylactic reaction emerges, the infusion needs to be promptly discontinued and the patient should not receive further infusions.
  • Patients receiving treatment with this medicinal product should be monitored for serum potassium, calcium, magnesium, creatinine, urea, urine output, liver function tests and CBC.
  • Patient management needs to include laboratory assessment of hepatic, renal, and hematopoietic function, and serum electrolytes (particularly potassium and magnesium).
  • Renal toxicity basically is dose dependent; dose adjustments need to be done only after assessing and considering the patient’s overall clinical picture.
How Supplied/Storage and Handling

Store unopened vials of lyophilized material at temperatures up to 25° C (77° F). The reconstituted product concentrate may be stored for up to 24 hours at 2°C to 8°C (36°F to 46°F) following reconstitution with Sterile Water for Injection. Do not freeze.

Commonly asked questions:

Amphotericin B Liposomal specifically is a lipid-associated formulation of the wide-spectrum polyene antifungal agent named amphotericin B. It is approved for the treatment of serious, life-threatening fungal infections including leishmaniasis, or a certain form of meningitis in individuals infected with HIV.

The liposomal amphotericin b 50 mg injection is supplied as single cartons (equivalent to 50mg) and in packs of ten individual vial cartons for intravenous administration.

Amphotericin B Liposomal for Injection is available in the dosage strength of 50 mg for intravenous powder for injection. 

Amphotericin B Liposomal specifically is a type of drug called antifungals.

You can buy liposomal amphotericin b from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the wholesaler/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product. 

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of the liposomal amphotericin b injection cost and procurement procedure.

Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.

 

Disclaimer

All Trademarks and Brands that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. We are NOT an ONLINE store and we do not sell Narcotics and Sedatives. Amphotericin B Liposomal is a pharmaceutical drug that legally requires a medical prescription to be dispensed. Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Cooperate Sourcing, reseller and Pharmacies.