• Innovator Brand Name - Otezla
  • Generic Brand Available - Aprezo
  • API - Apremilast
  • Packaging - 10 Tablets in a Strip
  • Strength - 10 mg, 20 mg, 30 mg


Apremilast, an inhibitor of phosphodiesterase 4 (PDE4), is indicated for the treatment of: 

  • Adult patients with active psoriatic arthritis. 
  • Patients with moderate to severe plaque psoriasis who are candidates for systemic or phototherapy therapy.
Apremilast Dosage
  • Dosing begins at 10mg on the first day with a gradual increase over 5 days, up to max dose of 30mg twice a day. In order to do so, it will reduce nausea and diarrhea linked with the initial treatment. Dosing should be the same for both psoriatic arthritis and plaque psoriasis. Apremilast tablets is a chronic drug that should be used without interrupting as long as it is useful, effective,Q and well-tolerated.
  • While receiving apremilast you should go to your rheumatologist (healthcare provider) at the regular basis in order to ensure that the treatment is useful and to minimise any probable adverse effects.
Apremilast side effects
  • The most common side effects of apremilast include vomiting, headache, back pain, nausea, diarrhea, fatigue, nasopharyngitis, upper respiratory tract infections, diarrhea, suicidal thoughts, and other mood changes.
  • Less common as well as rare possible adverse effects: Allergic reactions could appear with the use of apremilast. Seek medical help as soon as you can, if you become short of breath, suffer wheezing or have difficulty breathing, or if you have swelling of the face, lips, tongue, or other parts of the body.
Warnings and Precautions
  • Patients treated with Otezla 30 mg should have their weight monitored regularly. If unspecified or clinically significant weight loss appears, weight loss must be evaluated, and discontinuation of the Otezla should be considered.
  • Apremilast is contraindicated during pregnancy. It must be avoided.
  • Apremilast is a kind of specific and chronic drug that will be used without the interruption as long as it is well tolerated and effective.
  • Apremilast 30 mg is associated with an increased risk of depression. The risks and benefits of apremilast use should be carefully considered for patients with a history of depression or suicidal thoughts or behaviors.
  • Patients should be instructed to report increased depression, suicidal thoughts, or other mood changes to a healthcare provider.
  • Apremilast contains lactose, a type of sugar normally found in dairy products. This medicine may not be suitable for you if you have a lactose intolerance, which means that you can’t digest lactose normally.
  • If a patient is thinking about having surgery, check with their rheumatology team and surgeon about whether a patient should stop taking it for a time before and after surgery.
  • If patients develop severe diarrhoea, nausea, or vomiting, discontinuation of treatment with aprezo 30 mg tablet may be necessary.
  • Breastfeeding should be avoided while on this medication.
  • Otezla has not been specified in adolescents and children, therefore it should be not recommended for use in children and adolescents aged 17 years and under.
  • Patients with the known hypersensitivity to apremilast or to any of the excipients in the formulation should avoid it.
  • In missed dose circumstances, contact your healthcare provider or specialist team immediately for advice on when to take the next one.
  • Apremilast always should be stored in a cool and dry place, away from the direct heat and light (e.g. not in the bathroom).
  • If your healthcare provider instructs you in order to interrupt consuming your medicine, or if the expiry date has passed, return any unused apremilast tablets to your healthcare professional.
  • Never dispose of this medication through household waste or wastewater.
Supplied/Storage and handling

Care should be exercised in the handling of Apremilast generic. Tablets should not be opened or crushed. Do not store above 30°C.

Drug Indications:

Apremilast also can be used for treating adult patients with oral ulcers associated with Behçet’s Disease.

It is also useful for other immune system-related inflammatory diseases. It functions as a PDE4 and inhibits the spontaneous production of TNF-alpha from rheumatoid synovial cells in humans.

Commonly asked questions:

This drug acts as the selective inhibitor of the PDE4 (enzyme phosphodiesterase 4) and inhibits spontaneous production of the TNF-alpha from the human rheumatoid synovial cells.

Apremilast tablets are used in the treatment of psoriatic arthritis and moderate to severe plaque psoriasis.

The active ingredient is Apremilast with inactive ingredients such as lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, iron oxide red, iron oxide yellow, and iron oxide black.

Take the doses of the medicine as per the recommendation of the healthcare professional. One can take Apremilast without regard to meals. Do not crush, split, or chew the tablets.

In case of overdose, patients must seek medical help.

This medicine has not been studied in a pregnant woman or nursing mothers, so it effects on unborn babies and children remains unknown.

Depression and Weight loss are the serious side effects of this drug.

Apremilast should be taken as orally. It can be taken with or without food.

  • Apremilast 10 mg
  • Apremilast 20 mg
  • Apremilast 30 mg

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of Apremilast Price in India and the procurement procedure.
Note:- The order will be confirmed only after the receipt of Valid prescription of Clinician

Apremilast cost in India depends on multiple factors, like “generic brand you choose,” “strength you want,” etc. In India, multiple companies are manufacturing this medicine’s generic brand, and their cost varies.

Note: Always choose a legitimate pharmacy while buying any generic drug from India.


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