Bendamustine

  • Generic Brand Name - Bendit
  • Innovator Brand Name - Treanda
  • API - Bendamustine HCL
  • Packaging - Single-dose Vial
  • Strength - 100mg
  • Manufacturer Name - Natco Pharma Ltd.

What is Bendamustine and what it is used for:

Bendamustine is an alkylating medication used for the treatment of patients with CLL (Chronic lymphocytic leukemia), and Indolent B-cell non-Hodgkin’s lymphoma (NHL) that has progressed during or within 6 months of the treatment with rituximab or a rituximab containing regimen. 

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Dosage

The recommended dose for CLL is bendamustine 100 mg/m2, which should be administered intravenously (IV) over 30-minutes on the Days 1’st and 2’nd of a 28 day cycle, up to the 6-cycles.
The recommended dose for NHL is 120mg/m2, which should be administered intravenously over 60 minutes on Days 1’st and 2’nd of a 21 day cycle, up to the 8 cycles.

Bendamustine side effects
  • CLL: Most common adverse reactions include pyrexia, nausea, and vomiting.
  • NHL: Most common adverse reactions include nausea, vomiting, fatigue, diarrhea, anorexia, constipation, headache, weight decreased, rash, dyspnea, cough, stomatitis and pyrexia.
Warnings And Precautions
  • The bendit should not be used in patients with a known hypersensitivity to bendamustine or mannitol.
  • Patients on bendamustine injection should be monitored for the fever and other signs of the infection and should be treated promptly.
  • Patients receiving treatment with bendamustine hydrochloride should be monitored clinically and the drug should be discontinued in case of severe reactions.
  • Patients with myelosuppression after bendamustine injection 50 mg treatment should be advised to contact a doctor if they have signs or symptoms of infection.
  • Women with childbearing age should be advised to avoid becoming pregnant while on bendamustine 50 mg injection.
How Supplied/Storage and Handling:

Care should be exercised in the handling of BENDIT. BENDIT Injections should not be opened or broken. Store the vials up to 25°C (77°F) with excursions permitted up to the temperature 30°C (86°F).

Drug interaction of BENDAMUSTINE
  • Bendamustine’s active metabolites N-desmethyl-bendamustine (M4) and gamma-hydroxy bendamustine (M3) are formed through cytochrome P450 CYP1A2. Inhibitors of CYP1A2 (e.g., ciprofloxacin, fluvoxamine) have the potential to boost the plasma concentrations of bendamustine and reduce the plasma concentrations of active metabolites.
  • Inducers of CYP1A2 (e.g., smoking, omeprazole) have the potential to reduce the plasma concentrations of bendamustine and increase the plasma concentrations of its active metabolites.
  • Caution needs to be imposed, or alternative treatments considered in case concomitant treatment with CYP1A2 inhibitors or inducers are required.
  • In vitro findings suggest that the P-glycoprotein, breast cancer resistance protein (BCRP), and/or other efflux transporters may have a role in bendamustine transport. On behalf of Vitro findings, bendamustine is not likely to inhibit metabolism via human CYP isoenzymes CYP1A2, 2C9/10, 2D6, 2E1, or 3A4/5, or to induce the metabolism of substrates of cytochrome P450 enzymes.

Commonly asked questions:

FDA approved this drug in 2008 for the treatment of Chronic lymphocytic leukemia and many more.

Bendamustin hydrochloride is the active ingredient, and the inactive ingredient is mannitol.

Bendamustine specifically belongs to the class of drugs named alkylating agents. 

Fever, low blood cell counts, nausea, diarrhea, loss of appetite, cough, and rash

The recommended dose of bendamustine should be administered by injection into a vein.

Consult the doctor immediately and keep the patient under observation if the patient takes an overdose of the medicine Bendamustine. There is no antidote to the overdose of this drug. Overdose reactions may include sedation, tremor, ataxia, convulsions, and respiratory distress.

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Falls under the alkylating agent family of drugs, bendamustine works in order to interfere with the function of DNA and RNA.

The average wholesale price of bendamustine injection (25 mg/mL) is around 1,57,752 INR for a supply of 4 milliliters. 

You can buy Bendamustine Injection from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of Bendamustine and the procedure to buy.

Note:- The order will be confirmed only after the receipt of a Valid prescription of the Clinician.

Disclaimer

All Trademarks and Brands that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. Bendamustine Injection is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, Reseller and Pharmacies.