Cabozantinib

  • Innovator Name - Cometriq & Cabometyx
  • Generic Brand Available - Cabotres
  • API - Cabozantinib
  • Manufacturer Name - Cipla
  • Packaging - 30 Tablets
  • Strength - 40mg, 60mg

What is Cabozantinib, and what it is used for:

Cabozantinib is a kinase inhibitor used for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.

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Cabozantinib dosage

The recommended dose for advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) is cabozantinib 60 mg given once daily without food until the disease is progressive or unacceptable toxicity noticed.
Administer at least 1 hour before or at least 2 hours after eating. Do not substitute these tablets with cabozantinib capsules. Swallow the cabozantinib tablets whole. Do not crush the tablets. Do not take a missed dose within 12 hours of the next dose.

side effects

Commonly reported cabozantinib side effects include: diarrhea, decreased appetite, palmar-plantar erythrodysesthesia (PPE), nausea, fatigue, hypertension, and vomiting.

Warnings and Precautions
  • Stop treatment with cabozantinib at least 28 days prior to scheduled surgery, including dental surgery.
  • Do not administer cabozantinib 60 mg to patients with the recent history of hemorrhage, including hematemesis, hemoptysis, or melena.
  • Monitor patients with Cabozantinib for signs and symptoms of fistulas and perforations, including abscess and sepsis.
  • Monitor patients for blood pressure on a regular basis during Cabozantinib treatment.
    Wound complications have been reported with cabozantinib tablets. Stop the therapy at least 28 days prior to scheduled surgery.
  • Cabozantinib can cause fetal harm if administered to a pregnant woman.
    Advise women not to breastfeed during treatment with Cabozantinib and for 4 months following the last dose.
How Supplied/Storage and Handling:

Store cabozantinib tablets at temperature 20°C to 25°C (68°F to 77°F); excursions are permitted from temperature 15°C to 30°C (59°F to 86°F). Keep this medication out of sight and reach of the children.

Drug interaction of cabozantinib
  • Co-administration of a cabozantinib with a strong CYP3A4 inhibitor increased the exposure of cabozantinib, which may increase the risk of exposure-related adverse reactions. Do not administer cabozantinib along with strong CYP3A4 inhibitors. Reduce cabozantinib dosage if co-administration with strong CYP3A4 inhibitors cannot be avoided. Do not use grapefruit or grapefruit juice which may also increase the exposure of cabozantinib.
  • Co-administration of a cabozantinib with a strong CYP3A4 inducer reduced the exposure of cabozantinib, which may reduce efficacy. Do not administer cabozantinib along with strong CYP3A4 inducers. Increasing the cabozantinib dosage in the case of co-administration with strong CYP3A4 inducers cannot be avoided. Do not use St. John’s Wort which may also reduce the exposure of cabozantinib.

Commonly asked questions:

Cabozantinib specifically is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. 

Cabozantinib comes as a tablet and should be administered by mouth. 

  • cabozantinib 40 mg
  • cabozantinib 60 mg

Avoid drinking the grapefruit juice, eating the grapefruit or taking supplements that contain grapefruit or St. John’s wort during treatment with Cabozantinib.

You can buy Cabozantinib from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product. 

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of the cabozantinib cost and also the procurement procedure.

Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.

Disclaimer

All Trademark and Brand that appear on website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. We are NOT ONLINE store and We do not sell Narcotics and Sedatives. Cabozantinib is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Cooperate Sourcing, reseller and Pharmacies.