Cystadrops

Dosage form and strength

Cysteamine eye drops contain 3.8 mg/ml of cysteamine. This medicine comes in a 10 ml amber glass bottle.

Dosage and Administration

Description of dosage

• Instill one drop of Cystadrops in each eye 4 times a day.
• To avoid contamination of the solution, do not touch the dropper tip to the eyelids, surrounding areas, or any surface.
• In the case of related therapy with other topical ocular products, keep 10 minutes between successive applications. Administer the medicine at last.
• If the patient misses an instillation, ask the patient to administer a dose as soon as feasible and then continue the treatment with the next scheduled instillation. Discard the bottle of medicine after 7 days of the first opening.

Preparation and administration

• Professionals advise that patients store new, unopened Cystadrops bottles in the refrigerator in the original carton between 36°F-46°F (2°C-8°C).
• Each week, one should remove one new bottle from the refrigerator. Write the date of opening the bottle in the space on the carton. After the first opening, open the stored CYSTEAMINE ophthalmic at room temperature between 68°F to 77°F or 20°C to 25°C. Do not refrigerate the medicine after opening.
• Wash the hands carefully to avoid microbiological contamination of the content in the bottle.
• Then, remove the green protective cap.
• And remove the metal seal.
• Remove the gray stopper from the bottle.
• Patient should not touch the opening of the bottle after removing the gray stopper.

Overdose
There is no case of an overdose of CYSTEAMINE ophthalmic, but consult the doctor for worsening signs and symptoms if any patient takes an overdose.

Side effects

Every medicine has some side effects, and this medicine also has numerous side effects, which are categorized as:

Common side-effects

• Temporary eye discomfort
• Itching
• Pain
• Redness
• Blurred vision
• Sensitivity to light
• Vision changes

Uncommon side-effects

• Eyelid swelling
• Watery eyes
• Headache

Severe side-effects

• Severe allergic reaction
• Severe rash
• Itching/swelling
• Severe dizziness
• Trouble breathing, etc.

Note: Not every patient has these side effects; if any patient experiences the symptoms mentioned above or any other, consult the doctor immediately.

Precautions and Warnings

Contamination of solution and tips
To avoid the contamination of the dropper tip and solution, one should take care not to touch the eyelids or surrounding areas with the bottle’s dropper tip. Keep the bottle tightly closed when not in use.

Pseudotumor cerebri
There are reports of benign intracranial hypertension, also known as pseudotumor cerebri, associated with oral cysteamine treatment that has resolved with the addition of diuretic therapy. There are also reports associated with ophthalmic use of cysteamine; however, all of these patients were on concurrent oral cysteamine.

Use of contact lens
Cystadrops contain benzalkonium chloride, which soft contact lenses may absorb. Avoid contact with soft contact lenses, and one should remove the contact lenses before applying the solution, and one can reinsert the solution 15 minutes following its administration.

Storage instructions

Cysteamine ophthalmic solution 0.37% comes as a 5 ml sterile viscous solution in a 10 ml amber glass bottle closed by a bromobutyl stopper and sealed with an aluminum tear-off cap. A PVC dropper applicator with HDPE closure is packed separately and included in each carton box.
Each carton box contains 1 bottle and 1 dropper applicator individually wrapped.

Before First Opening: Before opening, store new, unopened medicine in the refrigerator between 36°F-46°F or 2°C-8°C. And to protect the drug from light, keep the bottle in the outer carton.

After First Opening: After opening, the store opened the medicine at room temperature between 68°F-77°F or 20°C-25°C. Do not refrigerate after opening. Keep the dropper bottle tightly closed in the outer carton to protect it from light. Discard 7 days after the first opening.