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Darunavir

  • Brand Name - Daruvir
  • Innovator Brand Name - Prezista
  • API - Darunavir Ethanolate
  • Packaging - 30 Tablets
  • Strength - 75mg, 150mg, 600mg, 800mg
  • Manufacturer Name - Cipla

WHAT IS DARUNAVIR AND WHAT IT IS USED FOR:

DARUNAVIR is a HIV protease inhibitor indicated for the treatment of: 

Human immunodeficiency virus (HIV): in adults and children 3 years of age and older. Darunavir is always used in combination with the HIV medicine ritonavir (Norvir) and other HIV medicines. This prescription medication was approved by the U.S. FDA (Food and Drug Administration).

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Darunavir Dosage

Darunavir should be taken orally at about the same time each day, either with or without food. Darunavir tablets should be swallowed whole with water. The tablets should not be opened, broken, or chewed.

Note:- The dose should be taken according to the consent of your healthcare providers.

Darunavir side effects

Most common side effects of Darunavir include fatigue, fever, loss of appetite, Diarrhea, nausea, rash, tenderness on your right side below your ribs, muscle or joint pain, tiredness, mouth sore, red eyes, headache, tea colored urine, abdominal pain and vomiting.

Warnings and Precautions
  • Darunavir 800 mg must be co-administered with ritonavir and food to achieve the desired antiviral effect. In absence of doing so darunavir with ritonavir and food may result in a loss of efficacy of darunavir.
  • Should monitor liver function prior and while on therapy, mainly in patients with underlying chronic hepatitis, cirrhosis, or in patients who have pre-treatment elevations of transaminases.
  • Post injury of the liver including fatalities in the patient suffering from cirrhosis or chronic hepatitis has been reported.
  • Skin reactions such as Stevens Johnson Syndrome, toxic epidermal necrolysis occurs.
  • Patients with Darunavir 600 mg may develop diabetes mellitus or hyperglycemia.
  • Not recommended to the patient suffering from sulfonamide allergy.
  • Not be used in pediatric patients of less than 3 years.
  • Daruvir/Ritonavir should not be used in patients with severe hepatic impairment.
  • The co-administration of Darunavir Ritonavir and PIs other than lopinavir ritonavir, atazanavir, saquinavir and indinavir has not been specified. Therefore this combination should be avoided.
  • It is not known whether darunavir is secreted in human milk, darunavir is secreted into the milk of lactating rats. Because of both the potential for Human Immunodeficiency Virus (HIV) transmission and the potential for severe side effects in nursing infants, mothers are advised they should avoid breastfeed while taking PREZISTA.
  • Population pharmacokinetic analysis showed higher mean darunavir exposure in HIV-1-infected females compared to males. This difference is not clinically relevant.
  • Population pharmacokinetic analysis of darunavir in HIV-1-infected subjects indicated that race had no apparent effect on the exposure to darunavir.
Supplied/Storage and handling

Care should be exercised in the handling of DARUNAVIR. Daruvir tablets should not be opened or crushed and should keep it in the tightly closed container. Store permitted between 20-25°C (68-77°F).

Interactions of Darunavir

Some studies have shown that this medication (Darunavir) may interact with some other drugs commonly received by patients with HIV/AIDS such as other antacids and antiretrovirals such as H2 receptor antagonists and proton pump inhibitors.

Co-administration of the Darunavir/ritonavir with some other medications may alter the concentration of other medications and other medications can alter the concentrations of darunavir. The potential drug-drug concentrations should be considered before and also as well as during the therapy.

The effect of darunavir may decrease by the St. John’s wort, which increased the breakdown of this drug by the metabolic enzyme CYP3A

Commonly asked questions:

Darunavir, mainly prescribed for HIV infection.

The active ingredient in the medicine is darunavir ethanolate, and the inactive ingredients are colloidal silicon dioxide, crospovidone, magnesium stearate, microcrystalline cellulose.

Darunavir medicine is an inhibitor of the HIV-1 protease. It selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteins in infected cells. Therefore it prevents the formation of mature virus particles.

Before taking medicine, Darunavir, one should run a medical checkup and acknowledge the healthcare provider of the medical history of all allergies and health-related problems.

  • Nausea
  • Diarrhoea
  • Increased Cholesterol
  • Increased Triglycerides
  • Darunavir 800mg
  • Darunavir 600mg
  • Darunavir 150mg
  • Darunavir 75mg

Yes. The FDA must first approve generic drugs before they are marketed. The FDA requires that generic drugs must be as high in quality, and as strong, pure and stable as brand name drugs.

  • You can buy Darunavir 800 mg, Darunavir 600 mg from any authorized whole seller after getting prescription from a qualified doctor. It is always better to check the credential of the whole seller/supplier/exporter before buying the product.
  • The buyer should check the existing law in their home country before importing the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of Pricing and procedure.
Note:- The order will be confirmed only after the receipt of Valid prescription of Clinician

Disclaimer

All Trademark and Brand that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. Darunavir is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, reseller and Pharmacies.