Dasatinib

  • Innovator Brand Name - Sprycel
  • API - Dasatinib
  • Generic Brand Available - Spnib
  • Packaging - 30/60 Tablets
  • Strength - 20mg/ 50mg/ 70mg/ 100 mg
  • Company - Zydus

What is Dasatinib, and what it is used for:

Dasatinib is a kinase inhibitor used to treat: 

  • Adult patients with newly diagnosed Philadelphia chromosome +Ve (Ph+) chronic myeloid leukemia (CML) in chronic phase. 
  • Adult patients with Ph+ CML who no longer benefit from, or did not tolerate, other therapy, including Gleevec (imatinib mesylate). 
  • Adult patients with Ph+ ALL (Acute Lymphoblastic Leukemia) who no longer benefit from, or did not tolerate, other therapy. 
  • Children with Ph+ chronic myeloid leukemia (Ph+ CML) in chronic phase. 
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Dosage

The recommended dose for adults with chronic phase CML is dasatinib 100 mg once daily. The recommended dose for adults with accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL is 140 mg once daily. The recommended starting dose for pediatrics with chronic phase CML is usually based on the body weight. Administer dasatinib orally, either with or without a meal. Do not crush, cut, or chew the tablets.

Side effects

Commonly reported side effects are incidence 15% in patients treated with dasatinib tablets include:

  • Myelosuppression
  • Fluid retention events
  • Diarrhea
  • Headache
  • Skin rash
  • Hemorrhage
  • Dyspnea
  • Fatigue
  • Nausea
  • Musculoskeletal pain
Warnings and Precautions
  • In patients with chronic phase CML and taking dasatinib 50 mg, perform CBCs every two weeks for 12 weeks, then every three months thereafter.
  • In patients taking dasatinib and with advanced phase CML or Ph+ ALL, CBCs need to perform weekly for initial two months and then monthly thereafter.
  • The dasatinib tablets can cause cardiac dysfunction. Assess patients for signs or symptoms consistent with cardiac dysfunction and treat accordingly.
  • Assess patients for signs/symptoms of underlying cardiopulmonary disease before initiating dasatinib and during therapy.
  • Because of potential for TLS, manage adequate hydration, correct uric acid levels before initiating therapy with dasatinib 100 mg tablet, and monitor electrolyte levels.
  • Females of reproductive potential should avoid pregnancy, which may include consideration of apt contraception while on therapy with dasatinib and for 30 days following the final dose.
  • Women should avoid breastfeeding during treatment with dasatinib and for 14 days following the final dose.
How Supplied/Storage and Handling:

The dasatinib tablets should be stored at 20°C to 25°C (68°F to 77°F); excursions permitted between temperature 15°C and 30°C (59°F and 86°F).

Drug interaction of Dasatinib
  • CYP3A4 Inhibitors may increase the drug levels of dasatinib and should be avoided. If co-administration cannot be avoided, monitor closely and consider decreasing dasatinib dose.
  • CYP3A4 Inducers may decrease the drug levels of dasatinib. In case co-administration cannot be avoided, consider increasing dasatinib dose.
  • The use of Antacids may reduce the drug levels of dasatinib. Avoid simultaneous administration. If required, administer the antacid at least 2 hours prior to or 2 hours after the dose of dasatinib.
  • The use of H2 Antagonists/Proton Pump inhibitors may decrease the drug levels of dasatinib. Consider antacids in place of H2 antagonists or proton pump inhibitors.

Commonly asked questions:

Dasatinib is aimed to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib is specifically used to treat cases that are Ph+ (Philadelphia chromosome-positive).

Dasatinib should be administered by mouth.

Yes, Dasatinib is a targeted therapy medication. 

You can buy Dasatinib from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of the dasatinib price and buying procedure.

Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.

Disclaimer

All Trademark and Brand that appear on website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. We are NOT ONLINE store and We do not sell Narcotics and Sedatives. Dasatinib is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Cooperate Sourcing, reseller and Pharmacies.