Metastatic Castration-Resistant Prostate Cancer

Exploring the Potential of PSCA-Targeted Chimeric Antigen Receptor T-Cell Therapy in Order to Treat mCRPC

  • March 30, 2021
  • 3 mins read

The mCRPC (Metastatic Castration-Resistant Prostate Cancer) remains a sort of deadly disease despite the improved treatment options for patients progressing on the standard hormone treatment.

New standards of care continue to be explored in order to treat patients with the metastatic castration resistant prostate cancer, including newly discovered immunotherapy options.

Treatment with immunotherapy has shown beyond doubt fruitful in establishing long lasting remissions for numerous cancer types. Nonetheless, that has yet to be literal for the mCRPC.

In patients with the refractory hematologic malignancies, chimeric antigen receptor (CAR) T-cell therapy has offered cures. Besides, the therapy demonstrates promise in solid tumors. Although, recognizing and selecting the best agent will be of paramount significance for the accomplishment.

A carried out Phase-I, investigation is underway exploring the application of the prostate stem cell antigen (PSCA), CAR T-cell therapy in patients with metastatic castration resistant prostate cancer.

Investigation is utilizing a toxicity sameness range in order to assess the picked doses of PSCA-BBζ cells in order to dictate the highest tolerated dose.

The 4-cohorts (1, 1b, 2, & 3) will each take a different dose of chimeric antigen receptor T cells. Cohort-1 will take 100 million chimeric antigen receptor T-cells, cohort-1b will take 100 million chimeric antigen receptor T-cells following lymphodepletion, cohort-2 will take 300 million chimeric antigen receptor T-cells following lymphodepletion, and cohort-3 will take 600 million chimeric antigen receptor T cells following lymphodepletion. The roughly calculated enrollment is 33 participants.

The Investigation has primary objectives of the safety as well as tolerability and defines the recommended phase-II dose. Secondary findings include evaluating the growth as well as determination of the PSCA chimeric antigen receptor T-cells and survival results.

To register, patients must have documented metastatic castration resistant prostate cancer previously taken treatment with either enzalutamide, abiraterone acetate, or both. Before chemotherapy, radium-223 is authorized but not needed.

Participants with a history of the optic neuritis or certain other inflammatory disease affecting their central nervous system can not participate.

So far numerous patients have been treated with PSCA-BBζ cells built up successfully and a single patient has demonstrated suggestions of the clinical as well as PSA responses to the treatment, but analysts are waiting for further statistics to appear prior to a reaction is established.

On behalf of an interview with the Targeted Oncology, Tanya B. Dorff, MD, a medical oncologist at the City of Hope Cancer Center, talked about the reasoning behind employing PSCA-targeted chimeric antigen receptor T-cell therapy and the arrangement of this early investigation. 



About mCRPC: The CRPC (castration-resistant prostate cancer) specifically is the form of advanced prostate cancer. With castration resistant prostate cancer, the cancer no longer completely responds to treatments that help in order to reduce testosterone. 

It demonstrates signs of growth, like a rising of prostate-specific antigen, even with reduced levels of testosterone. 

With Metastatic castration resistant prostate cancer, (mCRPC), the cancer stops responding to the hormone treatment, and it is found in the other organs of the body. It may spread to the nearby lymph nodes, bones, the bladder, liver, rectum, lungs, and probably the brain.

About Symptoms of mCRPC: There may be no signs/symptoms at all. In case there are the signs/symptoms from metastatic castration resistant prostate cancer, they depend on the size of the tumors and where the cancer has spread.

Signs of the metastatic castration-resistant prostate cancer include:

  • Trouble urinating
  • Weight loss
  • Shortness of breath
  • Bone pain
  • Feeling extremely tired or weaker than normal
  • Pain during passing urine
  • Blood in the urine

Prostate Cancer Awareness Month: Prostate Cancer Awareness Month takes place in the month of September in several nations. A light blue ribbon is used in order to promote the cause.