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Ibrutinib

  • Generic Brand Name - Ibrunat
  • Innovator Brand Name - Imbruvica
  • API - Ibrutinib
  • Packaging - 30 Capsules
  • Strength - 140 mg
  • Manufacturer Name - Natco Pharma

What is Ibrutinib and what it is used for:

Ibrutinib is a kinase inhibitor used for the treatment of adult patients with:

  • Mantle cell lymphoma (MCL)
  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL). 
  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion. 
  • Waldenström’s macroglobulinemia (WM). 
  • Marginal zone lymphoma (MZL). 
  • Chronic graft versus host disease (cGVHD). 
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Dosage

The recommended ibrutinib dose for patients with MCL and MZL is 560 mg, and for patients with CLL/SLL, WM, and cGVHD is 420 mg, which should be administered orally once daily. Dose should be administered orally with a glass of water. Do not open, break, or chew the capsules.

Ibrutinib side effects
  • The most common adverse reactions in patients with B-cell malignancies (MCL, CLL/SLL, WM and MZL) include neutropenia, hemorrhage, musculoskeletal pain, thrombocytopenia, rash, diarrhea, anemia, nausea, bruising, fatigue, and pyrexia.
  • The most common adverse reactions in patients with cGVHD include fatigue, muscle spasms, thrombocytopenia, bruising, diarrhea, anemia, stomatitis, hemorrhage, pneumonia, and nausea.
Warnings And Precautions
  • Patients with the therapy of ibrutinib 140 mg should be monitored and evaluated for fever and infections and treated appropriately.
  • Patients taking treatment with imbruvica generic should be monitored for the complete blood counts monthly.
  • Patients should be monitored for new onset hypertension or hypertension that is not adequately controlled after initiating therapy with ibrutinib tablets.
  • Patients during ibrutinib treatment should be monitored clinically for the cardiac arrhythmias.
  • Administration of ibrutinib 140 mg to pregnant and breastfeeding women should be avoided.
How Supplied/Storage and Handling:

Care should be exercised in the handling of the IBRUNAT. IBRUNAT tablets should not be opened or broken. Tablets should be stored in the original packaging at room temperature 20°C-25°C (68°F-77°F). Excursions permitted between temperature 15°C-30°C (59°F-86°F).

Drug interaction of ibrutinib
  • The coadministration of ibrutinib with a strong or moderate CYP3A inhibitor may increase plasma concentrations of ibrutinib. Increased concentrations of ibrutinib may increase the risk of drug-related toxicity.
  • Dose modifications are recommended when using ibrutinib along with voriconazole, posaconazole, and moderate CYP3A inhibitors.
    Avoid concomitant use of other strong CYP3A inhibitors. Interrupt ibrutinib therapy if these inhibitors will be used short-term (such as anti-infectives for seven days or less).
  • Do not use grapefruit and Seville oranges while on ibrutinib treatment, as these contain potent or moderate inhibitors of CYP3A.
  • The coadministration of ibrutinib therapy with strong CYP3A inducers may reduce ibrutinib concentrations. Avoid coadministration with strong CYP3A inducers.

Commonly asked questions:

Ibrutinib specifically belongs to the class of drugs named kinase inhibitors.

While taking Ibrunat 140 mg, consume at least 2-3 quarts of fluid in a day, unless you are instructed otherwise.

The recommended dose of ibrutinib tablet or capsules should be administered orally once daily at around the same time each day. Pills should be swallowed whole with water.

Ibrutinib is believed to target B cells and is therefore used for the treatment of B-cell lymphomas.

The average wholesale ibrutinib 140 mg price in India is around 8,991 INR for a supply of 30 capsules. Price also depends on “which Indian generic brand you choose

You can buy Ibrutinib from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of ibrutinib price and procedure.

Note:- The order will be confirmed only after the receipt of a Valid prescription of Clinician. 

Disclaimer

All Trademarks and Brands that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. Ibrutinib Tablet (Ibrunat) is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, Reseller and Pharmacies.