Lopinavir and Ritonavir HIV medicine should be taken orally at about the same time each day, either with or without food. Lopimune tablets should be gulped whole with water. The tablets should not be chewed, broken or crushed.
Lopimune(Lopinavir Ritonavir combination) is an HIV-1 protease inhibitor indicated for use in combination with other antiretroviral agents for adult and pediatric (14 days and older) patients with HIV-1 infection.
Lopinavir and Ritonavir HIV medicine should be taken orally at about the same time each day, either with or without food. Lopimune tablets should be gulped whole with water. The tablets should not be chewed, broken or crushed.
Care should be exercised in the handling of Lopinavir-Ritonavir. Lopinavir and Ritonavir tablets should not be opened or crushed. Store permitted between 15-30°C (59-86°F).
The combined Lopinavir ritonavir is anticipated to have varying degrees of interaction with other medications that are also CYP3A and/or P-gp substrates.
Use of Lopinavir Ritonavir is not recommended in order to be administered once daily in combination with Phenobarbital, Phenytoin (Dilantin) or carbamazepine (Carbatrol).
HIV-1, a protease inhibitor, is an antiviral drug that prevents the replication of the virus by selectively binding to viral proteases. It blocks proteolytic cleavage of protein precursors necessary for the production of infectious viral particles.
Yes, this combined medication can be used for prevention after a needlestick injury or other potential exposure.
In 2006, the United States (US) Department of Health and Human Services approved lopinavir/ritonavir as a first-line therapy for HIV.
Both the medications belong to the HIV protease inhibitors.
The active ingredients in the medicines are Lopinavir and Ritonavir, and the inactive ingredients are crospovidone, sorbitan monolaurate, colloidal silicon dioxide, and sodium stearyl fumarate.
As a single medication, Lopinavir ritonavir was approved for use in the United States in 2000.
Following patients should avoid the medicine Lopinavir Ritonavir:
Preterm neonates in the immediate postnatal period.
Patients with a history of pancreatitis.
Patients with diabetes mellitus or hyperglycemia.
Patients with hepatitis B or C.
Patients with hemophilia type A and B.
Patients with Immune reconstitution syndrome.
Breastfeeding and pregnant females.
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