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Nirmatrelvir / Ritonavir

  • Strength - NIRMATRELVIR 150MG AND RITONAVIR 100MG
  • Packaging - Tablet

What is Nirmatrelvir Ritonavir, and what it is used for?

The FDA has issued an EUA for the emergency use of the unapproved and co-packaged medications Nirmatrelvir, a SARS-CoV-2 main protease inhibitor, and Ritonavir, an HIV-1 protease inhibitor and CYP3A inhibitor, for the treatment of mild-to-moderate Coronavirus Disease 2019 (COVID-19) in adults and pediatric patients (aged 12 years and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing, and who are at higher risk for progression to severe COVID-19, including hospitalization or death.

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Dosage

Nirmatrelvir tablets co-packaged with ritonavir tablets, and must be co-administered. The proposed dosage is 300 mg nirmatrelvir (2 × 150 mg tablets) with 100 mg ritonavir (1 × 100 mg tablet) with all three tablets taken together by mouth (orally) twice daily for 5 days. Both nirmatrelvir and ritonavir tablets can be taken with or without food. Swallow the tablets whole and do not chew, break, or crush them.

The 5-day treatment course of Nirmatrelvir/Ritonavir needs to be initiated as promptly as possible once the diagnosis of COVID-19 has been made, and within 5 days of signs/symptom onset. Should a patient require hospitalization due to severe or critical COVID-19 after initiating treatment with

Nirmatrelvir/Ritonavir, the patient should finish the full 5-day treatment course per the health specialist’s discretion.
If the patient misses any dose of Nirmatrelvir/Ritonavir within 8 hours of the time-span it is usually taken, the patient should take it as quickly as possible and resume the general dosing schedule. If the patient misses any dose by excess than 8 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time. Do not take a couple of doses in order to make up for a missed dose.

Reference: https://bit.ly/3M5IqGf

Side effects

The most commonly reported Nirmatrelvir Ritonavir side effects include: dysgeusia, hypertension, diarrhea, and myalgia.

Warnings And Precautions
  • Use of Nirmatrelvir/Ritonavir is restricted in patients with a history of clinically significant hypersensitivity reactions (e.g., toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome) to nirmatrelvir/ritonavir or any other components of the product.
  • Nirmatrelvir must be co-administered along with ritonavir. Failure to correctly co-administer nirmatrelvir ritonavir tablets may result in plasma levels of nirmatrelvir that are not sufficient to achieve the required therapeutic effect.
  • Finishing the full 5-day treatment course and continued isolation in accordance with public health recommendations are crucial to maximize viral clearance and minimize the transmission of SARS-CoV-2.
  • Hepatic transaminase elevations, jaundice, and clinical hepatitis have been noted in patients receiving ritonavir. Therefore, caution should be exercised when using Nirmatrelvir/Ritonavir to patients with pre-existing liver diseases, liver enzyme abnormalities, or hepatitis.
  • Because nirmatrelvir tablets are co-administered with ritonavir, there may be a probability of HIV-1 establishing resistance to HIV protease inhibitors in people with uncontrolled or undiagnosed HIV-1 infection.
Storage and Handling

Store Nirmatrelvir 150 mg and Ritonavir 100 mg Tablets at USP controlled room temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).

Commonly asked questions:

Nirmatrelvir and Ritonavir is a co-packaged medication used as a treatment for COVID-19. It typically contains the antiviral medications nirmatrelvir and ritonavir.

Nirmatrelvir/Ritonavir is supplied in 150 mg/100 mg dosage strengths, in the form of Tablets. 

Nirmatrelvir Ritonavir is supplied as tablets for oral administration. 

Nirmatrelvir Ritonavir specifically are antiviral medicines. 

You can buy Nirmatrelvir Ritonavir from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product. 

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of the Nirmatrelvir Ritonavir price as well as the procurement procedure.

Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.

Disclaimer

All Trademarks and Brands that appear on website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. We are NOT ONLINE store and We do not sell Narcotics and Sedatives. Nirmatrelvir Ritonavir is a pharmaceutical drug that legally requires a medical prescription to be dispensed. Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Cooperate Sourcing, reseller and Pharmacies.