Paclitaxel

  • Brand Name - PacliALL
  • Innovator Brand Name - Taxol
  • API - Paclitaxel
  • Packaging - Single-use vial
  • Strength - 100 mg
  • Manufacturer Name - Panacea Biotec

WHAT IS PACLITAXEL AND WHAT IT IS USED FOR:

Paclitaxel is a prescription medicine indicated:

  • Together with other medications in order to treat primary breast cancer (cancer that has not spread beyond the breast or the lymph nodes under the arm) or it can be given as the part of a clinical trial for the primary breast cancer.
  • Alone or with other chemotherapy or anti-cancer drugs in order to treat breast cancer that has spread to areas around the breast such as the lymph nodes above or below the collarbone or to other organs of the body (secondary breast cancer). 
  • For the treatment of ovarian cancer 
  • For the treatment of lung cancer 
  • For the treatment of Kaposi’s sarcoma
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Pactlitaxel Dosage

Paclitaxel should be given as a drip into the vein (intravenously) in the arm or hand, although there are several other ways of giving it depending on the factors such as how simple it is for chemotherapy staff in order to find out the suitable veins and your preferences. It should be given over 3 hours once every 21 days, or once every 14 days (known as the accelerated or dose dense), or it can be given weekly in lower doses over one hour. The time gap between each cycle of the treatment will provide your body in order to recover properly, and can vary depending on whether the number of blood cells has returned to the normal between each cycle.

Pactlitaxel side effects

Most common adverse reactions include low red blood cell count (anemia), feeling weak or tired, hair loss, numbness, tingling, or burning in hands or feet, joint and muscle pain, trouble breathing, trouble swallowing, hives (raised bumps), rash, diarrhea, mouth or lip sores, (mucositis), infections, nausea, swelling of the hands, feet or face, vomiting, bleeding events, irritation at the injection site, low blood pressure (hypotension).

Warnings and Precautions
  • The use of this drug should be avoided in people who have allergic reactions to any of its ingredients.
  • Before taking paclitaxel, discuss with your doctor if you are pregnant or plan to become pregnant.
  • Discuss with your doctor, if you plan to breast-feed or breastfeeding. You together with your doctor should determine if you will take pacliall or breast-feed.
  • This medication should be avoided if you have low white blood cell counts.
  • You should not receive paclitaxel if you are allergic to medicines containing Cremophor.
  • Patients must be informed if they are being given other chemotherapy or anti-cancer drugs with paclitaxel, they may have additional side effects from these drugs.
  • Caution must be exercised when this medicine is concomitantly administered with the known substrates for instance repaglinide and rosiglitazone, inhibitors for instance gemfibrozil, and inducers for instance rifampin of CYP2C8.
  • For monitoring the occurrence of myelotoxicity, frequent peripheral blood cell counts must be performed on all the patients taking paclitaxel dose.
Supplied/Storage and handling

Care should be exercised in the handling of this drug. PACLIALL injection should not be opened or crushed. Should be Retained in the original package in order to protect from the light. Store the vials in original cartons between 20°–25° C (68°–77° F).

Drug interaction of Paclitaxel
  • The metabolism of Paclitaxel is catalyzed by cytochrome P450 isoenzymes CYP2C8 and CYP3A4. Caution should be imposed when Paclitaxel is concomitantly used with known substrates (eg, clarithromycin, midazolam, felodipine, buspirone, lovastatin, sildenafil, simvastatin, eletriptan, and triazolam), inhibitors (eg, itraconazole, atazanavir, indinavir, nefazodone, ketoconazole, nelfinavir, ritonavir, telithromycin and saquinavir), and inducers (eg, carbamazepine and rifampin ) of CYP3A4.
  • Caution should be imposed when Paclitaxel is concomitantly used with known substrates (eg, rosiglitazone and repaglinide ), inhibitors (eg, gemfibrozil), and inducers (eg, rifampin) of CYP2C8.
  • Reports suggest that plasma levels of doxorubicin (and its active metabolite doxorubicinol) may be increased when paclitaxel and doxorubicin are used in combination.

Commonly asked questions:

Yes, Paclitaxel chemotherapy medication recommended for use in order to treat several types of cancer.

For treating ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, prostate cancer, bladder cancer, cervical cancer, melanoma, esophageal, and pancreatic cancer are the uses of paclitaxel.

The active ingredient is Paclitaxel and the inactive ingredients are purified Cremophor EL (polyoxyethylated castor oil) and dehydrated alcohol.

Diarrhea, hair loss, bone marrow suppression, allergic reactions, numbness and muscle pains are the common paclitaxel side effects.

It works by interference with the normal function of microtubules during the cell division.

In 1971, Paclitaxel was initially isolated from the Pacific yew and in 1993 it was approved for medical use.

People who should avoid the administration of the medicine are as follows:
White blood cell count is below 1,500 cells/ mm3
Allergic to ingredients of the medicine.

  • If you purchase generic product then paclitaxel price is economical, You can buy it from any authorized whole seller after getting prescription from a qualified doctor. It is always better to check the credential of the whole seller/supplier/exporter before buying the product.
  • The buyer should check the existing law in their home country before importing the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of Pricing and procedure.
Note:- The order will be confirmed only after the receipt of Valid prescription of Clinician

Handle the medicine with care.
Do not open or crush the injection.
Keep in the original carton to protect it from the light.
Store the medicine at temperature 20°–25° C (68°–77° F).

Disclaimer

All Trademark and Brand that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. Paclitaxel Injection is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, reseller and Pharmacies.