In Mozobil 24 mg, the active substance named plerixafor mainly acts in order to block the activity of CXCR4 chemokine receptor, which normally helps in order to keep the stem cells within the bone marrow. By blocking its activity, Celrixafor helps enable the stem cells to be released into the blood, so that they collect.
Plerixafor
- Generic Brand Name - Celrixafor
- Innovator Brand Name - Mozobil
- API - Plerixafor
- Packaging - Single-Use Vial
- Strength - 24 Mg
- Manufacturer Name - Celon Labs Ltd, India.
What is Plerixafor and what it is used for:
Plerixafor specifically is a hematopoietic stem cell mobilizer indicated together with G-CSF in order to mobilize the hematopoietic stem cells to the peripheral blood for the collection and subsequent autologous transplantation in patients with NHL or MM.
Plerixafor Dosage
- Plerixafor 24mg is supplied in ready-to-use vials, and should be administered as a subcutaneous injection over the abdominal area. In case the needed volume exceeds 1.2mL, the dose can be split and should be given in 2 injections.
- Patients should be observed by nursing staff for an hour following each celrixafor dose with blood pressure and pulse monitored every 15 minutes.
In an event of drug overdose/missed dose, inform your healthcare practitioner as soon as possible.
Plerixafor side effects
Most common adverse reactions include nausea, diarrhea, injection site reactions, fatigue, headache, artralgia, vomiting, and dizziness.
Warnings And Precautions
- The plerixafor injection 20 mg/ml is not intended for the HSC mobilization and harvest in patients with leukemia.
- Patients should be monitored for the white blood cell counts during the use of this medication.
- All patients with this drug should be monitored for the platelet counts.
- Women of childbearng potential are advised to avoid conceiving a baby while receiving treatment with plerixafor injection 24 mg/1.2 ml.
- Nursing mothers are advised to discuss with their healthcare provider prior to starting breastfeeding.
- Advise patients about the signs and symptoms of the potential systemic reactions such as periorbital swelling, urticaria, dyspnea, or hypoxia while and after this injection.
- Instruct patients to contact healthcare practitioners immediately in case they have left upper abdominal pain or shoulder pain.
- Inform patients that the celrixafor may be responsible for causing the gastrointestinal disorders, including nausea, diarrhea, vomiting, abdominal pain, and flatulence.
Storage and Handling
Care should be exercised in the handling of Celrixafor. Celrixafor injections should not be opened or crushed. Store the vials at temp. 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F).
Drug interaction of Plerixafor
On behalf of in vitro data, Plerixafor is not a substrate, inhibitor, or inducer of human cytochrome P450 isozymes. It is not likely to be implicated in vivo drug-drug interactions involving cytochrome P450s. At concentrations identical to what are noted clinically, plerixafor did not act as a substrate or inhibitor of P-glycoprotein in an in vitro study.
Commonly asked questions:
Plerixafor is an inhibitor of the CXCR4 chemokine receptor and blocks binding of its cognate ligand, stromal cell-derived factor-lα(SDF-1α). It is more effective and less toxic than chemotherapy.
- Mozifor 24mg Injection (Hetero Healthcare Ltd)
- Plerimob 24mg Injection (Panacea Biotec Ltd)
- Stemfor Injection (Intas Pharmaceuticals Ltd)
The active ingredient in the medicine is Plerixafor, and the inactive ingredient is sodium chloride in Water for Injection.
Plerixafor injection belongs to the class of drugs named hematopoietic stem cell mobilizers.
Itching, rash, irritation at the site of injection, nausea, vomiting, diarrhea, stomach pain, bloating, gas, headache, dizziness, tiredness, and joint pain are the commonly reported plerixafor side effects.
The recommended dose of Plerixafor should be administered by subcutaneous injection based on the body weight.
Suppose one takes an overdose of Plerixafor overdose to consult the doctor and keep the patient under observation. According to the experience, patients had gastrointestinal disorders, vasovagal reactions, and orthostatic hypotension after an overdose.
The average wholesale price for a single vial of Celrixafor Injection is around 72000.
You can buy Plerixafor from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.
The buyer should check the existing law in their home country before importing the product.
Patients can simply fill the order form or can send mail at [email protected]. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of plerixafor injection price and procedure.
Note:- The order will be confirmed only after the receipt of Valid prescription of Clinician.
Disclaimer
All Trademark and Brand that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. Plerixafor 24mg injection is a pharmaceutical drug that legally requires a medical prescription to be dispensed.
Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, Reseller and Pharmacies.
