Polymyxin B

  • Generic Brand Name - Polykris
  • API - Polymyxin-B
  • Packaging - Single vial
  • Strength - 500000 IU

What is Polymyxin B, and what it is used for:

Polymyxin-B Injection is used to treat patients with the following infections when caused by susceptible strains of the designated aerobic gram-negative bacteria:

  • Urinary tract infections: Caused by the Pseudomonas aeruginosa and Escherichia coli. 
  • Bloodstream infections: Caused by the Pseudomonas aeruginosa, Enterobacter (formerly known as Aerobacter) aerogenes and Klebsiella pneumonia. 
  • Meningeal infections: Caused by the Pseudomonas aeruginosa. 
  • Corneal and subconjunctival eye infections: Caused by Pseudomonas aeruginosa.

The recommended dose of Polymyxin B Injection may be administered intravenously, intramuscularly or intrathecally only to hospitalized patients under the constant supervision by a healthcare professional. The polymyxin b dosage should not exceed 2.5 mg/kg/day or 200 mg/day.

side effects

The most commonly reported side effects of polymyxin B include neurotoxicity, pain at the injection site, electrolyte imbalance, and urticaria.

Warnings And Precautions
  • Therapy with polymyxin B USP 500000 IU shouldn’t be used in individuals with a prior history of hypersensitivity reactions to it.
  • The polymyxin B sulfate Injection, if prescribed for the administration of intravenous, intramuscular, or intrathecal, should be used only in hospitalized patients under precise monitoring for kidney function and neurological signs/symptoms.
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Inj polymyxin B dose and other antibacterial drugs, it should be used only to treat/prevent infections that are proven to be caused by susceptible bacteria.
  • The Inj polymyxin B dose should not be used in patients with myasthenia gravis.
  • Polymyxin-B Injection is nephrotoxic; therefore, the renal function should be evaluated before and regularly while on treatment.
  • Polymyxin-B sulphate injection should be used with extreme caution in patients with porphyria.
  • The polymyxin B uses are restricted during pregnancy unless the expected benefit to the mother outweighs any potential risk to the fetus.
How Supplied/Storage and Handling:

Care is exercised in the handling of Polymyxin B. It should not be open or broken. Polymyxin B Injection should be stored at temperature 20°C to 25°C (68°F to 77°F)

Drug Interaction
  • The concurrent use of other nephrotoxic/neurotoxic drugs, particularly bacitracin, streptomycin, kanamycin, tobramycin, cephaloridine, amikacin, cephalothin, polymyxin E (colistin), neomycin, vancomycin, and gentamicin, should be avoided.
  • Because of the effect of polymyxin antibiotic drug on the release of acetylcholine, depolarizing muscle relaxant succinylcholine and other neurotoxic drugs must not be used concurrently with polymyxin sulphate.
  • The concurrent use of polymyxin b sulphate with potent diuretics such as ethacrynic acid or furosemide should be avoided, since diuretics can enhance polymyxin B sulphate toxicity by altering the antibiotic concentration in serum and tissues.

Commonly asked questions:

Polymyxin-B is an antibiotic. It acts by breaking down the cytoplasmic membrane, which results in the death of bacterial cells.

The recommended dose of polymyxin b injection should be administered by injection into a vein, muscle, or intrathecally. 

You can buy Polymyxin-B directly from Ikris Pharma, make sure you have a valid prescription while buying.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of polymyxin b price and buying procedure.

Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.

Yes, Polykris is Polymyxin-B generic brand, It is manufactured by Ikris Pharma. For polymyxin b injection price in India Call/Whatsapp us on +91 8130290915, you can also dial our TOLL-FREE 18008891064 or mail us at info@ikrispharmanetwork.com


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