Sirolimus

  • Brand Name - Siromus
  • Innovator Brand Name - Rapamune
  • API - Sirolimus
  • Packaging - 6 capsules
  • Strength - 0.5mg, 1mg, 2mg
  • Manufacturer Name - Zydus

WHAT IS SIROLIMUS AND WHAT IT IS USED FOR:

Sirolimus or rapamycin is a macrolide compound that is indicated for the treatment of:

  • Lymphangioleiomyomatosis: A systemic disease and progressive disease that is responsible for causing cystic lung destruction.
  • Coat coronary stents: coronary stent is a tube-shaped device that is used to broaden the vein to or from that carry blood from the heart.
  • Prevent organ transplant rejection: it suppresses the immune system and reduces the chances of reduction of organ transplantation.
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Sirolimus Dosage

Sirolimus should be taken orally at about the same time each day, either with or without food. Sirolimus tablets should be swallowed whole with water. The tablet should not be opened, broken, or chewed.

Sirolimus tablets side effects

The most common side effects of Sirolimus are diarrhoea, pain, headache, abdominal pain, acne, chest pain, hypertension, hypertriglyceridemia, fever, hypercholesterolemia, creatinine, anaemia, nausea, urinary tract infection, arthralgia, sore throat, decreased glucose tolerance and insensitivity to insulin, dizziness, leg swelling, thrombocytopenia, and pain.

Warnings and Precautions
  • Sirolimus 1 mg is contraindicated in individuals with a known hypersensitivity to the drug.
  • In patients who are younger than 18 years old, the safety of LAM treatment by sirolimus has been not tested.
  • Sirolimus treatment can be responsible for the increased risk of diabetes type 2.
  • In the patients with sirolimus therapy especially in the case of lung transplants lung toxicity as a serious complication may occur.
  • There have been warnings about the use of sirolimus in transplants, where it may increase mortality due to an increased risk of infections.
  • Sirolimus tablets may increase an individual’s risk for contracting skin cancers from exposure to sunlight or UV radiation, and risk of developing lymphoma.
  • Individuals taking the siromus 1mg are at increased risk of experiencing impaired or delayed wound healing, particularly if they have a body mass index in excess of 30 kg/m2.
  • Sirolimus dosage or you can say rapamycin dosage is metabolized by the CYP3A4 enzyme and is a substrate of the P-glycoprotein (P-gp) efflux pump; hence, inhibitors of either protein may increase sirolimus concentrations in blood plasma, whereas inducers of P-gp and CYP3A4 may be responsible for the decrease in sirolimus concentrations in the blood plasma.
  • Women of childbearing potential should be recommended to avoid pregnancy while on or during the Rapamune therapy.
  • Siromus is not absorbed through the skin, there are no special precautions. Apart from this, if direct contact with the skin or mucous membranes occurs, immediately wash thoroughly with the help of soap and water also, rinse your eyes with normal water.
Supplied/Storage and handling

Care should be exercised in the handling of RAPAMUNE. RAPAMYCIN tablets should not be opened or crushed. Store permitted between 15-30°C (59-86°F).

Use cartons in order to protect blister cards and strips from light. Should be dispensed in the tight, light-resistant containers.

Commonly asked questions:

Sirolimus is recommended for the prevention of organ transplant rejection and for the treatment of LAM (lymphangioleiomyomatosis).

Sirolimus can also be used alone, or in conjunction with a calcineurin inhibitor (such as tacrolimus), and/or mycophenolate mofetil, to provide steroid-free immunosuppression regimens.

In the medicine, Sirolimus is the active ingredient, and the inactive ingredients are sucrose, lactose, polyethylene glycol 8000, calcium sulfate, microcrystalline cellulose, pharmaceutical glaze, talc, titanium dioxide, magnesium stearate, povidone, poloxamer 188, polyethylene glycol 20,000, glyceryl monooleate, carnauba wax, dl-alpha-tocopherol.

Yes, Sirolimus / Rapamycin was initially developed as an antifungal agent.

Sirolimus is a kind of a macrolide compound.

Yes, Sirolimus has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.

  • Sirolimus 0.5mg
  • Sirolimus 1mg
  • Sirolimus 2mg

If one takes an overdose of Sirolimus, they may experience some adverse reactions such as lymphoma, exfoliative dermatitis, Angioedema, Proteinuria, etc. Consult the doctor immediately and keep the patient under observation.

  • You can buy Sirolimus from any authorized whole seller after getting prescription from a qualified doctor. It is always better to check the credential of the whole seller/supplier/exporter before buying the product.
  • The buyer should check the existing law in their home country before importing the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patient can also send WhatsApp message to +91 8130290915. We will reply ASAP with the details of Pricing and procedure.
Note:- The order will be confirmed only after the receipt of Valid prescription of Clinician

Do not open or crush the capsules.
Store the medicine at temperature 15-30°C (59-86°F).

Disclaimer

All Trademark and Brand that appear on the website belong to their respective owners and Ikris Pharma Network does not lay and claim on them we only provide Information. Sirolimus is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, reseller and Pharmacies.