• Innovator Brand Name - Yondelis
  • Generic Brand Available - Trabec
  • API - Trabectedin
  • Packaging - Single-dose vial
  • Strength - 1mg
  • Manufacturer Name - Natco Pharma Ltd.

What is Trabectedin, and what it is used for:

Trabectedin is an alkylating medication used to treat patients with unresectable or metastatic liposarcoma or leiomyosarcoma who have taken an earlier anthracycline-containing regimen. 

Trabectedin dosage

The standard dose of Trabectedin is 1.5 mg/m2 which should be administered as an intravenous infusion over 24 hours through a central venous line every 3 weeks or 21 days, until the disease is progressive or unacceptable toxicity occurred, in patients with normal bilirubin and AST or ALT less than or equal to 2.5 times the upper limit of normal.

Side effects

Commonly reported trabectedin side effects include: constipation, nausea, fatigue, decreased appetite, peripheral edema, vomiting, diarrhea, dyspnea, headache.

Warnings and Precautions
  • Administer the dexamethasone 20 mg intravenously 30 minutes before each dose of Trabectedin.
  • Trabectedin 1 mg is contraindicated in patients with severe hypersensitivity, including anaphylaxis, to trabectedin.
  • Neutrophil count needs to be assessed before the administration of each dose of Trabectedin and then periodically throughout the therapy.
  • Assess LFTs before each administration of trabectedin injection. Manage the elevated LFTs with interruption of therapy, dose reduction, or permanent discontinuation based on severity and duration of LFT abnormality.
  • Assess left ventricular ejection fraction (LVEF) by echocardiogram or MUGA (Multigated Acquisition) scan prior to beginning of trabectedin and at 2-3 month intervals thereafter until the therapy is discontinued.
  • Based on its mechanism of action, trabectedin injection can cause fetal harm in cases administered to a pregnant woman.
  • Due to potential for severe adverse events from trabectedin in breastfed infants, nursing women are advised to interrupt nursing while on trabectedin treatment.
How Supplied/Storage and Handling:

Store Trabectedin vials in a refrigerator at 2°C to 8°C (36°F to 46°F). Trabectedin is a cytotoxic drug. Follow applicable special handling and disposal procedures.

Drug interaction of Trabectedin
  • Coadministration of Trabectedin with ketoconazole, a strong CYP3A inhibitor, increases systemic exposure of trabectedin by 66%. Avoid use of strong CYP3A inhibitors (e.g., oral ketoconazole, posaconazole, ritonavir, itraconazole, voriconazole, lopinavir, telithromycin, clarithromycin, indinavir, boceprevir, nelfinavir, saquinavir, telaprevir, nefazodone, conivaptan) in patients with therapy of Trabectedin. Do not take grapefruit or grapefruit juice while on Trabectedin therapy. In case a strong CYP3A inhibitor for short-term use (i.e., less than 14 days) must be used, administer the strong CYP3A inhibitor 7 days after the Trabectedin infusion, and discontinue it the day prior to the next Trabectedin infusion.
  • Coadministration of Trabectedin with rifampin, a strong CYP3A inducer, decreased systemic exposure of trabectedin by 31 percent. Do not administer strong CYP3A inducers (e.g., phenobarbital, rifampin, St. John’s wort) to patients with Trabectedin.

Commonly asked questions:

Trabectedin specifically is an antitumor chemo medicine aimed to treat advanced soft-tissue sarcoma and ovarian cancer.

Trabectedin 0.25 mg should be administered as an intravenous infusion. 

You will not be given trabectedin if you have had a severe allergic reaction to Trabectedin. 

Patients are advised to avoid grapefruit as well as grapefruit juice while on therapy with Trabectedin.

You can buy Trabectedin from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product. 

Patients can simply fill the order form or can send mail at Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of the trabectedin price in India and procurement procedure.

Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.


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