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Treosulfan

  • Generic Brand Name - Emtreo
  • Innovator Brand Name - Trecondi
  • API - Treosulfan
  • Packaging - 1 Vial
  • Strength - 5gm
  • Manufacturer Name - Emcure Pharma Ltd.

What is Treosulfan, and what it is used for:

Treosulfan is an alkylating agent. It is used to prepare patients for bone marrow transplants (hematopoietic stem cell transplantation). The treosulfan injection is used before the blood stem cell transplantation in adult patients with cancer and non-cancerous disorders and children and adolescents aged older than 30 days with cancer.

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Dosage

The recommended dose of treosulfan injection is 10-14 g/m² body surface area administered by drip (infusion) into a vein over 2 hours for three days before the blood stem cell infusion. For adults, Emtreo injection is used together with fludarabine, and for children/adolescents, it is used along with fludarabine, and in most cases, together with thiotepa.

Treatment Reaction

Most common adverse reactions in adults and children include infections, nausea (feeling sick), stomatitis (inflammation of the lining of the mouth), vomiting, diarrhea, and bellyache. Tiredness, low white blood cell counts with fever, high blood levels of bilirubin are also reported in adult patients, and rash also affects children.

Warnings And Precautions
  • Patients with treosulfan 5g injection should be monitored for blood cell counts frequently until recovery of the hematopoietic system.
  • Concomitant use/application of live attenuated vaccines is not allowed.
  • The treosulfan 5gm injection might impair fertility in men as well as women. Therefore, men must seek advice on cryo-conservation of sperm before treatment due to the probability of irreversible infertility.
  • Sexually active men/women of childbearing potential have to use apt and effective contraception while up to 6 months following treatment.
  • Use of treosulfan 5g injection is contraindicated during pregnancy.
  • Breast-feeding should be discontinued during treosulfan injection treatment.
  • Treosulfan injection has a moderate influence on the ability to drive as well as use machines.
How Supplied/Storage and Handling:

Care is exercised in the handling of EMTREO. Injection should not be open or broken. Emtreo Injection should be stored at room temperature, away from heat and direct light. Do not freeze it.

Drug interaction of TREOSULFAN
  • No interaction of treosulfan was noted in high-dose chemo regimens.
  • Detailed in vitro findings did not entirely exclude potential interactions between high plasma concentrations of treosulfan and CYP3A4, CYP2C19, or P-gp substrates. Therefore, medicinal products with a narrow therapeutic index (e.g. digoxin) that are substrates for CYP3A4, CYP2C19, or P-gp should not be used while on treatment with treosulfan.
  • The treosulfan effect on the pharmacokinetics of fludarabine is not known.

Commonly asked questions:

The treosulfan 5gm is used as a part of a conditioning regimen in stem cell transplantation.

Treosulfan belongs to the class of drugs named bifunctional alkylating agents. 

The recommended dose of treosulfan injection should be administered by intravenous (IV) infusion over 30 minutes. 

You can buy Treosulfan from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.

The buyer should check the existing law in their home country before importing the product.

Patients can simply fill the order form or can send mail at info@ikrispharmanetwork.com. Patients can also send WhatsApp messages to +91 8130290915 or can dial Toll-Free number: 18008891064. We will reply ASAP with the details of treosulfan cost and buying procedure.

Note:- The order will confirm only after the receipt of the Valid prescription of the Clinician.

Disclaimer

All Trademarks and Brands that appear on the website belong to their respective owners, and Ikris Pharma Network does not claim them. We only provide details. Treosulfan Injection is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Following Information meant for Wholesalers, Suppliers, Exporters, Doctors, Comparator Supplies, Hospitals, Generic, Brand, Corporate Sourcing, Reseller, and Pharmacies.